Gene therapy (cancer)
Nemunaitis, John Department of Oncology, Mary Crowley Cancer Research Centers, Dallas, Texas.
- Signal targeting
- Gene therapeutics
- RNA interference
- Links to Primary Literature
- Additional Readings
Since 1970, the median survival of patients having advanced cancer with optimal standard systemic treatment has remained less than 1 year. To increase survival rates, gene therapy has emerged as a new cancer treatment plan. Gene therapy is defined as the introduction of a functional copy of a curative gene into a patient in order to achieve a therapeutic objective. In 1973, a technique to introduce DNA into mammalian cells was developed. The first preclinical attempt to use gene insertion for therapy in animals was done in 1994. In this case, a growth hormone gene was inserted into cells and injected into mice with deficient growth hormone production. The growth hormone gene was introduced successfully, and a functional protein product was expressed as a result. Since then, gene therapy has progressed, providing opportunities for many new directions in cancer management. One opportunity can be characterized as a process involving “personalized molecular therapeutics.” There are six key alternatives of the neoplastic physiolome (a set of physiologic features) that dictate malignant growth: (1) self-sufficiency; (2) insensitivity to growth inhibition, including immune escape (the ability to avoid immune-mediated rejection); (3) independence from programmed cell death (apoptosis); (4) unlimited replicative potential; (5) sustained angiogenesis (the development of blood vessels); and (6) local/distal tissue invasion capacity.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Its dedicated editorial team is led by Sagan Award winner John Rennie. Contributors include more than 9000 highly qualified scientists and 39 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 17,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information