Helper and regulatory T cells
Piccirillo, Ciriaco A. Center for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada.
- Th1/Th2 model of T-cell regulation
- Differentiation of T helper cells
- Regulatory T cells
- Future research
- Links to Primary Literature
- Additional Readings
The immune system has evolved complex processes to ensure tolerance to autoantigens (self antigens) while preserving the potential to mount effective humoral (mediated by antibodies secreted by B lymphocytes, or B cells) and cellular (mediated by T lymphocytes, or T cells) immune responses against invading pathogens. The establishment of an immune response to various foreign antigens involves a complex interplay of not only pathogen-related factors that influence infectivity but also host-related factors that help mount, sustain, and control the necessary adaptive immune responses against the pathogen. Indeed, when a pathogen invades its host, an innate and T helper (Th) cell–dominated adaptive immune response is induced, clearing the infection and, most importantly, establishing life-long immunity to the pathogen. (Note that Th cells are also known as CD4+ cells.)
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Its dedicated editorial team is led by Sagan Award winner John Rennie. Contributors include more than 9000 highly qualified scientists and 39 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 17,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information