Waldmann, Katherine S. National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.
Waldmann, Thomas A. Metabolism Branch, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.
Turk, J. L. Department of Pathology, Royal College of Surgeons of England, London, United Kingdom.
- Suppressor cells
- Regulation of normal immune response
- Mechanisms of suppressor cell action
- Disorders of suppressor cell regulation
- Drug-induced immunosuppression
- Drug-induced immunological tolerance
- Drug-induced potentiation of immune response
- Links to Primary Literature
- Additional Readings
The natural or induced active suppression of the immune response, as contrasted with deficiency or absence of components of the immune system. Like many other complex biological processes, the immune response is controlled by a series of regulatory factors. A variety of suppressor cells play a role in essentially all of the known immunoregulatory mechanisms, such as maintenance of immunological tolerance; limitation of antibody response to antigens of both thymic-dependent and thymic-independent types, as well as to antigens that stimulate reaginic antibody (antibodies involved in allergic reactions); genetic control of the immune response; idiotype suppression; control of contact and delayed hypersensitivity; and antigenic competition. All of the major cell types [macrophages (monocytes), bone marrow–derived lymphocytes that normally mature into antibody-producing cells (B cells), and especially thymus-derived lymphocytes (T cells)] involved in the positive side of cellular interactions required for an immune response have also been found capable of functioning as suppressors in different regulatory systems. See also: Immunological deficiency
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Its dedicated editorial team is led by Sagan Award winner John Rennie. Contributors include more than 9000 highly qualified scientists and 39 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 17,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information